When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells

Figure 2

Application of the lncRNA knockout in PSCs. The lncRNA gene knockout can be done through (a) knocking out the whole lncRNA gene from the genome, (b) knocking out part of the lncRNA gene, (c) knocking out the lncRNA promoter region, and (d) inserting poly(A) signal (pA) after the transcription start site. (e) Application of genome editing to study lncRNA functions in ESCs. (f) Application of genome editing in ESC to generate lncRNA-knockout mice.