Review Article
When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells
Table 2
Classification of lncRNA functional mechanisms and the location of lncRNAs.
| Mechanism of function | Examples | Ref. |
| Nucleus | Regulating chromatin-modifying complexes | ANRIL | [47] | HOTAIR | [48] | Recruiting transcription factors | HERVH | [17] | PWR1 | [49] | TUNA | [50] | Chromatin remodeling | HOTTIP | [51] | SRG1 | [52] | fbp1 ncRNA | [53] | Influencing pre-mRNA splicing | MALAT1 | [18] | EGFR-AS1 | [54] | Cytoplasm | Regulating mRNA stability | Linc-RoR | [55] | Gadd7 | [56] | MEG3 | [57] | Regulating mRNA translation | lincRNA-p21 | [19] | Antisense Uchl1 | [58] | Competing for microRNA binding | HPAT5 | [59] | HULC | [60] | Translated in biologically active small peptides | LINC00961 | [61] |
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