Stem Cells International

Research Article

The Optimal Intervention Time of Bone Marrow Mesenchymal Stem Cells in Ameliorating Cardiac Fibrosis Induced by Viral Myocarditis: A Randomized Controlled Trial in Mice

Table 1

Echocardiography on the 28th day after CVB3 inoculation. for each group.


Parameters	Control	VMC	VMC1d + BMSCs	VMC3d + BMSCs	VMC1w + BMSCs	VMC2w + BMSCs

Heart rate (beats/min)	509 ± 31	521 ± 30	531 ± 39	535 ± 14	533 ± 16	529 ± 31
LVAWd (mm)	0.736 ± 0.058	0.557 ± 0.079^aa	0.597 ± 0.031^a	0.593 ± 0.086^a	0.610 ± 0.039^a	0.648 ± 0.113
LVAWs (mm)	1.210 ± 0.102	0.735 ± 0.077^aa	0.960 ± 0.100^a,b	1.036 ± 0.178^bb	1.029 ± 0.095^bb	1.023 ± 0.179^bb
LVPWd (mm)	0.721 ± 0.106	0.546 ± 0.068^a	0.592 ± 0.047	0.590 ± 0.089^a	0.611 ± 0.066	0.645 ± 0.120
LVPWs (mm)	1.125 ± 0.153	0.811 ± 0.120^aa	0.952 ± 0.116	0.923 ± 0.130	1.029 ± 0.139^b	1.010 ± 0.172
LVIDd (mm)	3.684 ± 0.255	3.941 ± 0.366	3.593 ± 0.387	3.645 ± 0.267	3.440 ± 0.459	3.466 ± 0.410
LVIDs (mm)	2.149 ± 0.300	2.970 ± 0.375^aa	2.410 ± 0.459^b	2.600 ± 0.221	2.004 ± 0.328^bb,c	2.139 ± 0.349^bb
LVEDV (μl)	55.61 ± 13.22	68.40 ± 14.61	55.03 ± 13.93	56.57 ± 9.30	50.02 ± 15.39	50.74 ± 14.41
LVESV (μl)	15.79 ± 5.62	34.93 ± 10.77^aa	21.53 ± 10.41^b	24.90 ± 5.09	13.39 ± 5.32^bb,c	15.79 ± 6.59^bb
LVEF (%)	71.98 ± 5.149	49.55 ± 6.999^aa	62.41 ± 9.749^b	60.22 ± 6.673^b	70.51 ± 6.166^bb,c	69.74 ± 4.763^bb
FS (%)	40.59 ± 4.303	24.81 ± 4.145^aa	33.33 ± 6.554^b	31.74 ± 4.617	39.10 ± 4.71^bb,c	38.53 ± 3.54^bb

LVAWs: left ventricular anterior wall during systole; LVAWd: left ventricular anterior wall during diastole; LVPWs: left ventricular posterior wall during systole; LVPWd: left ventricular posterior wall during diastole; LVIDs: left ventricular internal diameter at end-systole; LVIDd: left ventricular internal diameter at end-diastole; LVESV: left ventricular end-systolic volume; LVEDV: left ventricular end-diastole volume; LVEF: left ventricular ejection fraction; FS: fractional shortening). ^a when compared to the control group; ^aa when compared to the control group; ^b when compared to the VMC group; ^bb when compared to the VMC group; and ^c when compared to the VMC3d + BMSCs group.