Mesenchymal Stem Cells Promoted Lung Wound Repair through Hox A9 during Endotoxemia-Induced Acute Lung Injury

Figure 2

Protective action of MSCs was determined by survival rate and HE staining. (a) The survival assay. The survival rate was nearly 50% at 72 h, and administration of MSCs significantly increased survival rate to 90%. (b) HE staining at 24 hours after MSCs administration. The lung tissues from the LPS group demonstrated significantly pathological alterations, which was attenuated by MSCs administration. (c) Distribution of MSCs at 24 hours after MSCs administration. Fluorescence was distributed throughout the distal lungs when administrating MSCs into normal rats; however, the fluorescence was mainly distributed in larger blood vessels when administrating MSCs into ALI Rats. (d) HE staining at 7 days after MSCs administration. Lung injury was obviously attenuated by MSCs administration.

(a)

(b)

(c)

(d)