Stem Cells International

Review Article

A Molecular and Clinical Review of Stem Cell Therapy in Critical Limb Ischemia

Table 1

Clinical trials using stem cells for treatment of peripheral artery disease related critical limb ischemia.


Trial number	Phase	Study period	Route	Treatment

NCT00883870	1 and 2	4/2009–3/2011	IM	Ex vivo cultured adult allogeneic MSCs versus plasmalyte A
NCT00616980	1 and 2	12/2007–10/2010	IM	Autologous CD34⁺ cells
NCT00919958	1	06/2009–06/2010	IM	Allogeneic PLX-PAD
NCT00951210	1	08/2009–10/2011	IM	Allogeneic PLX-PAD
NCT01049919	1 and 2	06/2010–05/2014	IM	Autologous concentrated BM aspirate using MarroStim PAD kit
NCT00468000	2	04/2007–03/2011	IM	Autologous BM cells
NCT00987363	1 and 2	07/2009–12/2011	IA	Autologous BM-derived MNCs
NCT01019681	1	11/2009–11/2015	IM	Umbilical cord blood stem cells
NCT00872326	1 and 2	12/2007–05/2009	IA	Autologous BM-derived MNCs
NCT00523731	1	01/2006–03/2007	IM	Autologous, nonmobilized angiogenic cell precursor
NCT00392509	1 and 2	10/2006–12/2008	IM	Aldehyde dehydrogenase bright stem and progenitor cells
NCT01079403	1 and 2	12/2009–12/2011	IA	Autologous adipose tissue-derived MSCs
NCT00498069	1 and 2	11/2007–12/2014	IM	Autologous BM aspirate
NCT00922389	1 and 2	07/2009–01/2011	IM	G-CSF⁺ PB-derived MNCs
NCT00913900	1	05/2009–09/2012	IM	Autologous CD133⁺ cells
NCT00371371	1 and 2	11/2006–07/2013	IA	Autologous BM-derived MNCs
NCT00721006	2	11/2006–12/2010	SC (40x)	Combination of SCT
NCT01065337	2	10/2004–02/2009	IM/IA	Autologous BM-derived MNCs versus tissue repair cell CD90⁺ cells
NCT00533104	1 and 2	10/2004–02/2009	IM (30x)	Autologous PB-derived MNCs and BM-derived MNCs
NCT00595257	1 and 2	12/2007–08/2010	IM	Autologous BM aspirate using SmartPREP2
NCT00434616	2 and 3	04/2007–07/2011	IM	Autologous BM cell concentrate
NCT00904501	3	03/2009–06/2014	IM	Autologous BM-derived MNCs
NCT00488020	1	04/2006–06/2007	IM (40x)	Autologous BM-derived MNCs
NCT00518401	1	06/2007–10/2009	IM (40x)	Combination of stem cell mixture
NCT00221143	1 and 2	11/2003–01/2008	IM (40x)	Autologous PB CD34⁺ cells
NCT00539266	2 and 3	10/2007–10/2010	IM	Autologous BM-derived MNCs (DM versus non-DM)
NCT00145262	2	08/2003–	IM	Autologous BM-derived MNCs
NCT00282646	1 and 2	10/2005–03/2011	IA	Autologous BM-derived MNCs
NCT02538978	3	08/2015–07/2016	IM	Autologous BM cells using SurgWerksTM-CLI kit and VXPTM system
NCT01386216	1	06/2011–01/2017	IM	Autologous BM aspirate using Magellan system
NCT01558908	1 and 2	03/2012–	IM	Endometrial regenerative cells
NCT02551679	2	11/2015–	IM	Autologous angiogenic cell precursors
NCT02140931	2	05/2014–11/2015	IM	Autologous angiogenic cell precursors

BM: bone marrow; BM-MNC: bone marrow mononuclear cell; DM: diabetes mellitus; G-CSF: granulocyte colony-stimulating factor; IA: intra-arterial; IM: intramuscular; MSC: mesenchymal stem cell; PAD: peripheral arterial disease; PB: peripheral blood; PB-MNC: peripheral blood mononuclear cell; PLX-PAD: placental-derived mesenchymal stem cells; SC: subcutaneous.