Long-Term Safety of Transplanting Human Bone Marrow Stromal Cells into the Extravascular Spaces of the Choroid of Rabbits

Table 1

Mean retinal thickness in rabbit eyes before and following hBM-MSC transplantation.

	Total retina	RNFL	GCL	IPL	INL	OPL	ONL	RPE	ORL	Choroid	Sclera
Baseline	182.5 ± 0.5	4 ± 1	6.8 ± 1.5	11.6 ± 0.0	6 ± 0.6	14 ± 1.3	61.5 ± 0.8	12.6 ± 1	65.8 ± 0.5	92.7 ± 8.7	232 ± 3.2
1 h	195.3 ± 3.7 (p0 = 0.07)	6 ± 2.5 (p0 = 0.6)	7.6 ± 1.9 (p0 = 0.8)	11.7 ± 0.7 (p0 = 0.9)	6.8 ± 1.2 (p0 = 0.7)	15.9 ± 4.4 (p0 = 0.8)	64.5 ± 3 (p0 = 0.5)	14 ± 0.9 (p0 = 0.5)	68.3 ± 0.7 (p0 = 0.3)	236.8 ± 15.6 (p0 = 0.006)	243.8 ± 11.1 (p0 = 0.5)
10 w	166.7 ± 16 (p0 = 0.43, p1 = 0.11)	8.9 ± 3.9 (p0 = 0.34, p1 = 0.6)	8.3 ± 1.3 (p0 = 0.54, p1 = 0.84)	16.4 ± 4.7 (p0 = 0.42, p1 = 0.29)	9.2 ± 2.2 (p0 = 0.3, p1 = 0.4)	12.5 ± 2.8 (p0 = 0.7, p1 = 0.6)	42.1 ± 18 (p0 = 0.4, p1 = 0.2)	12.1 ± 0.5 (p0 = 0.7, p1 = 0.2)	62.8 ± 1.5 (p0 = 0.2, p1 = 0.07)	104.9 ± 13.2 (p0 = 0.5, p1 = 0.009)	259.9 ± 1.2 (p0 = 0.2, p1 = 0.7)

Comparison of retinal thickness measurements (in μm) using SD-OCT in rabbit eyes before (baseline), 1 hour (1 h), and 10 weeks (10 w) following hBMSC transplantation. All data are presented as mean ± SE from 4 different areas from 2 (baseline, 10 weeks) or 3 (1 hour) rabbits. Scleral thickness was measured from the outer scleral border to the choroid/sclera interface. Student’s t-test was used to evaluate differences in retinal thickness measurements between baseline and following transplantation (p₀) and between 1 hour and 10 weeks (p₁) following transplantation. RNFL: retina nerve fiber layer; GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer; RPE: retinal pigment epithelium; ORL: outer retina layer. Total retina was measured from RNFL to ORL.