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Stem Cells International
Volume 2017, Article ID 4364302, 11 pages
https://doi.org/10.1155/2017/4364302
Research Article

Optogenetic Inhibition of Striatal Neuronal Activity Improves the Survival of Transplanted Neural Stem Cells and Neurological Outcomes after Ischemic Stroke in Mice

1Neuroscience and Neuroengineering Research Center, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
2Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China
3Department of Human Anatomy, Guangzhou Medical University, Guangzhou 510182, China
4Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China

Correspondence should be addressed to Guo-Yuan Yang; moc.361@6260gnayyg and Yongting Wang; moc.liamg@gnaw.gnitgnoy

Received 27 March 2017; Revised 25 June 2017; Accepted 18 July 2017; Published 14 September 2017

Academic Editor: Hailiang Tang

Copyright © 2017 Yifan Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1. The time mouse spent to pass the beam in the beam walk test. No significant difference was observed in the four groups at 3 days before tMCAO (PBS ⁼ 2.9 ± 0. 7, NSC ⁼ 2.9 ± 0. 3, NSC-E ⁼ 2.8 ± 0.2, NSC-I ⁼ 3.0 ± 0. 4, n6) and 3 days after tMCAO (PBS ⁼ 9.6 ± 2.3, NSC ⁼ 10.4 ± 2.1, NSC-E ⁼ 9.2 ± 1.9, NSC-I ⁼ 9.8 ± 1.7, n6). At 14 days, NSC-I group passed the beam significantly faster than the PBS control group (NSC-I ⁼ 4.8 ± 0. 9 vs PBS ⁼ 7.7 ± 1.8, n6). Though not significant, NSC-Igroupspend15.1% less time than NSC group (NSC-I ⁼ 4.8 ± 0. 9, NSC ⁼ 5.9 ± 1.4, n6), NSC-E group spend 20.1% more time than NSC group (NSC-E ⁼ 7.2 ± 1.7, NSC ⁼ 5.9 ± 1.4, n6). represents p<0.05.

  1. Supplementary Material