TNF-α Induced the Enhanced Apoptosis of Mesenchymal Stem Cells in Ankylosing Spondylitis by Overexpressing TRAIL-R2

Figure 2

ASMSCs were more susceptible to TNF-α/CHX-induced apoptosis compared to HDMSCs. (a) Apoptosis of HDMSCs () and ASMSCs () was determined using FCM. Cells in the upper-right and lower-right quadrants represent apoptotic cells; the apoptotic rate was calculated in (b). After a 6-hour culture, only treatment with TNF-α/CHX induced significant MSC apoptosis. Treatment with control medium or with TNF-α or CHX alone did not induce significant apoptosis. ASMSCs had a higher rate of apoptosis than HDMSCs in the TNF-α/CHX treatment group. Values are presented as the mean ± SD. indicates between HDMSCs and ASMSCs. indicates for the control group compared with the other HDMSC groups. $ indicates for the control group compared with the other ASMSC groups.

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