The Transcription Factor Nrf2 Protects Angiogenic Capacity of Endothelial Colony-Forming Cells in High-Oxygen Radical Stress Conditions

Figure 1

Nrf2 pathway modulation—effects on gene expression: (a) transduction with shRNAs against Nrf2 resulted in a significant reduction in Nrf2 expression (). No effect on Keap1 was observed. (b) shRNAs against Keap1 reduced its expression (). (c) Effects of shRNAs on Nrf2/ARE target gene HO-1. shNrf2 transduction induced a reduction in HO-1 expression () and shKeap1 increased HO-1 expression (). All experiments reflect data from 3 independent replicates.

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