Review Article

The Use of Adipose-Derived Stem Cells in Selected Skin Diseases (Vitiligo, Alopecia, and Nonhealing Wounds)

Table 2

List of past and present clinical adipose-derived stem cell trials on chronic wound [80].

NumberStudyApplication methodConditionsPhaseTrial institution/sponsor and countryNCT number and duration period

(1)Adipose derived Regenerative Cellular Therapy of Chronic WoundsInjections to the woundVenous ulcer, diabetic foot, pressure ulcerIITower Outpatient Clinic, Los Angeles, California, USANCT02092870
2013–2015
(2)ADSCs and Pressure UlcersInjections (stromal vascular fraction) to rim around the venous stasis of the woundChronic venous stasis woundsISanford Plastic and Reconstructive Surgery Clinic, Sioux Falls, USANCT02961699
2017–2020
(3)ADSCs and Pressure UlcersInjected into a fibrin sealant applicator and applied to the woundPressure ulcerIMayo Clinic, Florida, USANCT02375802
2015–2017
(4)Safety of Adipose-Derived Stem Cell Stromal Vascular FractionInjections with or without unprocessed autologous fat (fresh or cryopreserved)Abnormally healing wounds, scars, and soft tissue defectsIAdiSave Inc., CanadaNCT02590042
2015–2019
(5)Assessment of the Efficacy and Tolerance of Sub-cutaneous Re-injection of Autologous Adipose-derived REGEnerative Cellsin the Local Treatment of Neuropathic Diabetic Foot ulcERs (REGENDER)Injections to the woundDiabetic foot ulcerIIAssistance Publique Hopitaux De Marseille, FranceNCT02866565
2017–2019
(6)Treatment of Hypertensive Leg Ulcer by Adipose Tissue GraftingAdipose tissue grafting (lipofilling)Hypertensive leg ulcerIUniversity Hospital, Caen, FranceNCT01932021
2013–2014
(7)Safety of ALLO-ASC-DFU in the Patients with Diabetic Foot UlcersALLO-ASC-DFUDiabetic foot ulcerIAsan Medical Center, Seoul, South KoreaNCT02394886
2014–2015
(8)The Role of Lipoaspirate Injection in the Treatment of Diabetic Lower Extremity Wounds and Venous Stasis UlcersInjection of lipoaspirateDiabetic wounds, venous stasis woundsWashington DC Veterans Affairs Medical Center, USANCT00815217
2009–2010
(9)Allogeneic ADSCs and Platelet-Poor Plasma Fibrin Hydrogel to Treat the Patients With Burn WoundsApplied by surface application over perforated (1 : 3) autologous skin graftSecond- or third-degree burnsI, IIThe Kyiv City Clinical Hospital, UkraineNCT03113747
2015–2018
(10)Safety of ADSCs Stromal Vascular FractionInjections (stromal vascular fraction) to the wound fresh or cryopreserved autologous fatAbnormally healing wounds, scars, and soft tissue defectsIForest Hill Institute of Aesthetic Plastic Surgery, Toronto, Ontario, CanadaNCT02590042
2015–2019
(11)Child’s Adipose Cells: Capacity of Tissue RegenerationAdipose tissue sample in children < 10 y.A nude mouse model of skin burnCHU de Toulouse-Purpan, Tolouse, FranceNCT02779205
2015–2017
(12)A Study to Evaluate the Safety of ALLO-ASC-DFU in the Subjects With Deep Second-degree Burn WoundA hydrogel sheet containing allogenic ASCDeep second-degree burn wound patientsIHallym University of Medical Center, Seoul, Republic of KoreaNCT02394873
2015
(13)ADSCs for the Treatment of Perianal Fistula in Crohn Disease: A Pilot Study (ASPEFIC1)ADSC injectionPerianal fistula Crohn’s diseaseIIPapa Giovanni XXIII Hospital, ItalyNCT02403232
2014–2018
(14)Autologous Cultured Adipose-Derived Stem Cells (ANTG-ASC) on Complex and Crohn’s FistulaADSC injectionPerianal fistula
Crohn’s disease
IISeoul National University Hospital, Republic of KoreaNCT01314092
2011–2016
(15)Adipose-Derived Stem Cells to Treat Complex Perianal FistulasADSC injection and dressing with fibrin gluePerianal fistulasIGeneral Surgery Department, Hospital Universitario La Paz, SpainNCT01020825
2009–2011