Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer

Figure 3

Stem cell-related transcription factors and cancer stem cells are enriched in TNBC cells. (a) The alteration rates of stem cell-related transcription factors (SC-TFs) in TCGA breast cancer samples () or TCGA TNBC samples (). (b) The expression levels of SC-TFs were elevated in TNBC cells including basal-like and claudin-low. The expression data of the indicated SC-TFs were retrieved from breast cancer cell lines dataset (ArrayExpress accession number E-MTAB-181) by suing UCSC Cancer Genomic Browser according to the instructions. (c) The population of CSCs was higher in basal-like cells MDA-MB231 but lower in luminal subtype of cells SKBR3. The population of CSCs was determined by the staining of stem cell marker followed by flow cytometry. (d) The expression levels of CDH1, 2, 4, 6, and 17 in TNBC claudin-low MDA-MB231 cells and luminal subtype of cells SKBR3. The expression data of CDH1, 2, 4, 6, and 17 in both cell lines were retrieved from the same dataset as described in (b).

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