Stem Cells International

Research Article

Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer

Table 1

Cooccurrence of stem cell-related transcription factors in association with alterations of CDH2, 4, 6, and 17.


Gene A (CDH)	Gene B (SC-TF)		log odds

CDH2	MCM2	<0.001	1.340	Tendency for cooccurrence, significant
	WWTR1	<0.001	1.235	Tendency for cooccurrence, significant
	FOXO3	0.003	1.080	Tendency for cooccurrence, significant
	FOXM1	0.019	0.763	Tendency for cooccurrence, significant
	SNAI1	0.022	0.864	Tendency for cooccurrence, significant
	SOX9	0.099	0.553	Tendency for cooccurrence, marginal

CDH4	FOXM1	<0.001	1.256	Tendency for cooccurrence, significant
	MCM2	<0.001	1.181	Tendency for cooccurrence, significant
	SNAI1	<0.001	2.421	Tendency for cooccurrence, significant
	SOX9	<0.001	1.088	Tendency for cooccurrence, significant
	NANOG	0.004	1.281	Tendency for cooccurrence, significant
	POU5F1	0.004	0.949	Tendency for cooccurrence, significant
	HMGA1	0.005	0.854	Tendency for cooccurrence, significant
	MYC	0.017	0.494	Tendency for cooccurrence, significant
	WWTR1	0.057	0.472	Tendency for cooccurrence, marginal
	HIF1A	0.063	0.653	Tendency for cooccurrence, marginal

CDH6	GLI2	<0.001	1.532	Tendency for cooccurrence, significant
	WWTR1	<0.001	1.151	Tendency for cooccurrence, significant
	ZEB1	<0.001	1.737	Tendency for cooccurrence, significant
	FOXM1	0.005	0.827	Tendency for cooccurrence, significant
	KLF4	0.028	1.093	Tendency for cooccurrence, significant
	SNAI1	0.039	0.710	Tendency for cooccurrence, significant
	POU5F1	0.043	0.768	Tendency for cooccurrence, significant
	NANOG	0.062	0.968	Tendency for cooccurrence, marginal
	MCM2	0.071	0.593	Tendency for cooccurrence, marginal

CDH17	PRDM14	<0.001	2.551	Tendency for cooccurrence, significant
	LIN28B	<0.001	1.122	Tendency for cooccurrence, significant
	MYC	<0.001	>3	Tendency for cooccurrence, significant
	FOXM1	0.008	0.556	Tendency for cooccurrence, significant
	SNAI1	0.008	0.662	Tendency for cooccurrence, significant
	STAT3	0.009	0.692	Tendency for cooccurrence, significant
	SOX9	0.035	0.466	Tendency for cooccurrence, significant
	LIN28A	0.040	0.842	Tendency for cooccurrence, significant
	KLF4	0.041	−1.276	Tendency towards mutual exclusivity, significant
	GLI2	0.043	−0.842	Tendency towards mutual exclusivity, significant
	MCM2	0.048	0.460	Tendency for cooccurrence, significant
	TBX3	0.069	−0.693	Tendency towards mutual exclusivity, marginal
	FOXO3	0.073	0.418	Tendency for cooccurrence, marginal
	ZEB1	0.086	−0.653	Tendency towards mutual exclusivity, marginal

Note. , cadherin: here including CDH2, 4, 6, and 17. , stem cell-related transcription factor. SC-TFs in bold indicate that their occurrence simultaneously happened with the alterations of 3 or 4 CDHs mentioned in a. values are derived from Fisher’s exact test; values less than 0.1 are included. odds ratio indicates the likelihood that the events in genes A and B are mutually exclusive or cooccurrent across the selected cases. The value quantifies how strongly the presence or absence of alterations in gene A is associated with the presence or absence of alterations in gene B in the selected cases. odds ratio > 0: association towards cooccurrence; log odds ratio ≤ 0: association towards mutual exclusivity; significant means value < 0.05; marginal means value is 0.05–0.1.