Cadherins Associate with Distinct Stem Cell-Related Transcription Factors to Coordinate the Maintenance of Stemness in Triple-Negative Breast Cancer

Table 6

Top 10 perturbagens identified through the Connectivity Map that anticorrelated with the CDH-associated signature.

Pharmaceutical perturbagen	Enrichment CMap score			value
Resveratrol	−0.765	1	9	<0.00001	A stilbenoid, a type of natural phenol
Trifluoperazine	−0.553	2	16	<0.00001	A blocker of dopamine D1/D2 receptor
0297417-0002B	−0.981	3	3	0.00004	N.D.
MG-262	−0.939	9	3	0.00032	A proteasome inhibitor
Apigenin	−0.866	10	4	0.00062	A potent inhibitor of CYP2C9; a monoamine transporter activator; a ligand for central benzodiazepine receptors
Pyrvinium	−0.740	11	6	0.00066	An antinematodal agent
Methotrexate	−0.654	12	8	0.00078	An inhibitor of dihydrofolate reductase (DHFR), participating in DNA repair; a suppressant of immunology
Amiodarone	−0.777	15	5	0.00096	A calcium channel blocker
Piperidolate	−0.908	19	3	0.00142	An antimuscarinic
Acepromazine	−0.811	24	4	0.00251	A phenothiazine derivative antipsychotic drug

Note. by value. indicates the number of instances related to these perturbagens tested in the Connectivity Map. .D., not determined.