Combined Analysis of Endothelial, Hematopoietic, and Mesenchymal Stem Cell Compartments Shows Simultaneous but Independent Effects of Age and Heart Disease

Figure 6

Effect of LV dysfunction (LVD) and cardiovascular risk factors (age over 65 years, diabetes mellitus, and smoking) on bone marrow stem cell compartments. (a) Number of mononuclear cells isolated from the sternal bone marrow. Results of clonogenic assay (CFU) and flow cytometry analyses (FACS) of mesenchymal stem cells (MSCs, (b)), endothelial progenitor cells (EPCs, (c), (d)), and hematopoietic stem cells (HSCs, (e), (f)). Student’s t-test and Mann–Whitney test. DM: Diabetes mellitus. + or −: presence or absence.

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