Combined Analysis of Endothelial, Hematopoietic, and Mesenchymal Stem Cell Compartments Shows Simultaneous but Independent Effects of Age and Heart Disease

Table 3

Frequency of endothelial progenitor cells, hematopoietic stem cells, and mesenchymal stem cells in the sternal bone marrow samples from patients classified according to the EuroSCORE and SYNTAX score. Cells were analyzed by colony assay (CFU) and flow cytometry (FACS).

Cell population (assay)	EuroSCORE			SYNTAX score
	Low risk ()	Intermediate risk ()		Low risk ()	Intermediate risk ()
EPCs (CFU)	1.40 (0–5.0)	0.3 (0–14.0)	0.826	1.5 (0–15.5)	1.0 (0–8.6)	0.980
EPCs (FACS)	190.3 ± 62.4	174.0 ± 39.0	0.012	186.0 ± 49.0	158.0 ± 29.0	0.021
HSCs (CFU)	81.0 (8.0–230.0)	68.5 (5.0–142.5)	0.862	81.0 (9.5–220.0)	52.0 (6.0–127.5)	0.685
HSCs (FACS)	20.3 ± 4.5	18.0 ± 6.0	0.083	21.0 ± 9.0	17.0 ± 4.0	0.005
MSCs (CFU)	0.6 (0–6.0)	0.2 (0–0.4)	0.200	0.8 (0–10)	0.4 (0–4.0)	0.824

EPCs: endothelial progenitor cells; HSCs: hematopoietic stem cells; MSCs: mesenchymal stem cells. The results are presented as mean and standard deviation, or median and interquartile range. value, Student’s t-test and Mann–Whitney test.