Stem Cells International / 2017 / Article / Tab 2

Research Article

Evaluating Wharton’s Jelly-Derived Mesenchymal Stem Cell’s Survival, Migration, and Expression of Wound Repair Markers under Conditions of Ischemia-Like Stress

Table 2

Differentially expressed wound healing genes, between control and ischemic WJ-MSCs, as determined by quantitative analysis using PCR array.
(a) Genes ≥ 2.0-fold in ischemic WJ-MSCs as compared to control WJ-MSCs

Number Gene symbol Gene description Fold difference

1.ACTA2Actin, alpha 2, smooth muscle, aorta
2.COL14A1Collagen, type XIV, alpha 1
3.COL1A1Collagen, type I, alpha 1
4.COL1A2Collagen, type I, alpha 2
5.COL3A1Collagen, type III, alpha 1
6.COL4A1Collagen, type IV, alpha 1
7.COL4A3Collagen, type IV, alpha 3 (Goodpasture antigen)
8.COL5A1Collagen, type V, alpha 1
9.CTSKCathepsin K
10.CXCL11Chemokine (C-X-C motif) ligand 11
11.IGF1Insulin-like growth factor 1 (somatomedin C)
12.IL4Interleukin 4
13.IL6Interleukin 6 (interferon, beta 2)
14.ITGA1Integrin, alpha 1
15.MMP2Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase)
16.PDGFAPlatelet-derived growth factor alpha polypeptide
17.PTENPhosphatase and tensin homolog
18.TGFATransforming growth factor, alpha
19.TIMP1TIMP metallopeptidase inhibitor 3
20.VGEFAVascular endothelial growth factor A
21.VTNVitronectin
22.WISP1WNT1 inducible signaling pathway protein 1

(b) Genes downregulated ≥ 2.0 in ischemic WJ-MSCs as compared to control WJ-MSCs

NumberGene symbolGene descriptionFold difference

1.CCL2Chemokine (C-C motif) ligand 2
2.CCL7Chemokine (C-C motif) ligand 7
3.CSF2Colony stimulating factor 2 (granulocyte-macrophage)
4.CTSVCathepsin L2
5.CXCL1Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
6.CXCL2Chemokine (C-X-C motif) ligand 2
7.HGFHepatocyte growth factor (hepapoietin A; scatter factor)
8.IL2Interleukin 2
9.ITGA6Integrin, alpha 6
10.ITGB6Integrin, beta 6
11.MMP1Matrix metallopeptidase 1 (interstitial collagenase)
12.PLGPlasminogen
13.TNFTumor necrosis factor
14.WNT5AWingless-type MMTV integration site family, member 5A

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