Evaluating Wharton’s Jelly-Derived Mesenchymal Stem Cell’s Survival, Migration, and Expression of Wound Repair Markers under Conditions of Ischemia-Like Stress
Table 2
Differentially expressed wound healing genes, between control and ischemic WJ-MSCs, as determined by quantitative analysis using PCR array.
(a) Genes ≥ 2.0-fold in ischemic WJ-MSCs as compared to control WJ-MSCs
Number
Gene symbol
Gene description
Fold difference
1.
ACTA2
Actin, alpha 2, smooth muscle, aorta
2.
COL14A1
Collagen, type XIV, alpha 1
3.
COL1A1
Collagen, type I, alpha 1
4.
COL1A2
Collagen, type I, alpha 2
5.
COL3A1
Collagen, type III, alpha 1
6.
COL4A1
Collagen, type IV, alpha 1
7.
COL4A3
Collagen, type IV, alpha 3 (Goodpasture antigen)
8.
COL5A1
Collagen, type V, alpha 1
9.
CTSK
Cathepsin K
10.
CXCL11
Chemokine (C-X-C motif) ligand 11
11.
IGF1
Insulin-like growth factor 1 (somatomedin C)
12.
IL4
Interleukin 4
13.
IL6
Interleukin 6 (interferon, beta 2)
14.
ITGA1
Integrin, alpha 1
15.
MMP2
Matrix metallopeptidase 2 (gelatinase A, 72 kDa gelatinase, 72 kDa type IV collagenase)
16.
PDGFA
Platelet-derived growth factor alpha polypeptide
17.
PTEN
Phosphatase and tensin homolog
18.
TGFA
Transforming growth factor, alpha
19.
TIMP1
TIMP metallopeptidase inhibitor 3
20.
VGEFA
Vascular endothelial growth factor A
21.
VTN
Vitronectin
22.
WISP1
WNT1 inducible signaling pathway protein 1
(b) Genes downregulated ≥ 2.0 in ischemic WJ-MSCs as compared to control WJ-MSCs
