Stem Cells International / 2017 / Article / Fig 4

Research Article

Predicting the Remaining Lifespan and Cultivation-Related Loss of Osteogenic Capacity of Bone Marrow Multipotential Stromal Cells Applicable across a Broad Donor Age Range

Figure 4

Combination of SPARC and other parameters with predictive potential for MSC culture longevity. (a) No relationship between T/S ratio and PD-BS (left; solid: culture expanded, hollow: postosteogenic induction), but correlation between SPARC × [T/S ratio] and PD-BS (solid line: linear regression; dotted line: 95% confidence). (b) Left: 95% confidence in calculated values of SPARC × [1/PRAMEF2] in relation to PB-BS (shaded area ≤5 PD-BS); right: relationship between SPARC × [1/PRAMEF2] and CFU-O (c). Prediction model of calculation values <5 being indicative of higher remaining PD-BS (left) and osteogenic potential (right). Whisker range 2.5%–97.5% confidence, line at median.

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