Predicting the Remaining Lifespan and Cultivation-Related Loss of Osteogenic Capacity of Bone Marrow Multipotential Stromal Cells Applicable across a Broad Donor Age Range
Table 2
Transcript relationships with PD-BS and osteoprogenitor indicators.
Gene
Correlation with PD-BS (rho = ())
Gradient
Range (min–max)
Also related to PD?
Relationship with CFU-O?
Relationship with Ca++?
Higher expression closer to senescence
ACVR2A
−0.454
−0.0727
0.07–3.41
Y
Y
Y
ALPL
−0.348
−0.1095
0.03–5.26
Y
Y
ANGPTL4
−0.422
−0.0336
0.01–1.57
Y
Y
BAMBI
−0.454
−0.2279
0.29–8.67
Y
Y
Y
BMPER
−0.686
−0.0985
0.06–9.28
Y
Y
Y
COL1A1
−0.551
−7.2721
6.35–302
Y
Y
Y
COL1A2
−0.340
−10.771
14.6–632
FGFR1
−0.453
−0.2315
0.61–13.6
Y
Y
FZD4
−0.477
−0.0789
0.07–12.2
Y
Y
IGFBP3
−0.417
−5.1189
8.78–236
Y
Y
JAG1
−0.465
−0.1876
0.25–27.0
Y
SFRP4
−0.511
−0.1091
0.004–35.4
Y
Y
Y
SORT1
−0.331
−0.1515
0.134–5.68
Y
Y
SPARC
−0.753
−16.614
33.2–545
Y
Y
Y
TNFRSF11B
−0.642
−0.7225
0.179–29.2
Y
Y
Y
Lower expression closer to senescence
CEBPA
0.358
0.0012
0.001–0.119
Y
SFRP1
0.369
0.0034
0.002–0.634
Y
SOX2
0.390
0.3751
0.005–22.9
Y
; ; Y (yes) = ; empty = no significance. Strongest candidate for prediction model based on multiple correlations and steepest gradient.
