Mesenchymal Stem Cells Promote Metastasis of Lung Cancer Cells by Downregulating Systemic Antitumor Immune Response

Figure 5

MSCs attenuate antitumor cytotoxicity of NK cells in iNOS and IDO-dependent manner. The total number of (a) CD49b+ and (b) CD49b+ NKG2D+ cells in the lungs of control, LLC1, and LLC1 + MSC-treated mice at the 28th day of the experiment. (c-d). The results obtained by xCELLigence system showed cytotoxic activity of NK cells against LLC1 target cells. Data presented as mean ± SEM; mice per experimental groups. , , and .

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