Review Article

Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

Figure 1

Tunneling nanotube (TNT). Tunneling nanotubes can connect many different cells together, using cytoskeleton actin microfilaments, microtubules, or both. TNTs allow the trafficking, from donor to recipient cells, of cargoes including organelles, proteins, miRNAs, and ions.