Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy

<div>Mitochondrial trafficking from MSCs to MDA-MB-231 breast cancer cells. (a) MSC mitochondrial network. MSCs were labeled by MitoTracker Deep Red FM and Green CellTracker CMFDA. Scale bars, 10 <i>μ</i>m. (b) Transfer of MSC mitochondria to MDA-MB-231 cells. Coculture (24 h) of human MSCs (MitoTracker Red CMXRos prestained) and MDA-MB-231 cells (Green CellTracker CMFDA prestained). (A) 2D view of the coculture, (B, C) 3D reconstruction of the cells from stacks of confocal images with the cell isosurface view (B), and <i>xy</i> plane section (C) (Imaris). Scales, (A) 50 <i>μ</i>m, (B, C) 10 <i>μ</i>m.</div>

Stem Cells International

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Figure 2: Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy 

Figure 2 | Cell Connections by Tunneling Nanotubes: Effects of Mitochondrial Trafficking on Target Cell Metabolism, Homeostasis, and Response to Therapy 