Molecular Mutations and Their Cooccurrences in Cytogenetically Normal Acute Myeloid Leukemia

Table 2

Cooccurrent or mutually exclusive alterations and their significance in genes of interests.

Gene A	Gene B	value	Odds ratio	Association	⁢
ASXL1	IDH2	0.003	2.241	Tendency towards cooccurrence	Significant
IDH1	DNMT3A	0.005	1.266	Tendency towards cooccurrence	Significant
TET2	DNMT3A	0.01	1.156	Tendency towards cooccurrence	Significant
DNMT3A	FLT3	0.035	0.713	Tendency towards cooccurrence	Significant
KMT2A	DNMT3A	0.042	−1.169	Tendency towards mutual exclusivity	Significant
IDH2	KMT2A	0.056	1.052	Tendency towards cooccurrence	Marginal

Database used for analysis is TCGA, NEJM 2013 [94]. The database contains all 166 complete tumors of AML. Query was performed on 10 genes which include ASXL1, BCOR, TET2, IDH1, IDH2, RUNX1, PHF6, KMT2A (MLL), DNMT3A, and FLT3. The query results contain 23 gene pairs with mutually exclusive alterations (1 significant) and 22 gene pairs with cooccurrent alterations (4 significant, 1 marginal).