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Stem Cells International
Volume 2017, Article ID 7012405, 11 pages
Research Article

BMP4/LIF or RA/Forskolin Suppresses the Proliferation of Neural Stem Cells Derived from Adult Monkey Brain

1Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, China
2School of Medicine, Jiaxing University, Zhejiang 314001, China
3Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, China
4Changzheng Hospital, Second Hospital Affiliated with Second Military Medical University, Shanghai 200003, China
5Tongji University Advanced Institute of Translational Medicine, Shanghai 200092, China

Correspondence should be addressed to Xinxin Han; nc.ude.naduf@nahxx, Hua He; moc.anis@hh9791adnap, and Zhengliang Gao; nc.ude.ijgnot@oag_gnailgnehz

Received 19 May 2017; Revised 22 July 2017; Accepted 24 August 2017; Published 20 September 2017

Academic Editor: Yao Li

Copyright © 2017 Xinxin Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Monkeys are much closer to human and are the most common nonhuman primates which are used in biomedical studies. Neural progenitor cells can originate from the hippocampus of adult monkeys. Despite a few reports, the detailed properties of monkey neural stem cells (NSCs) and their responses to cytokine are still unclear. Here, we derive NSCs from an adult monkey brain and demonstrate that BMP4 inhibits cell proliferation and affects cell morphology of monkey NSCs. Combined treatment of BMP4 and LIF or RA and Forskolin represses the proliferation of monkey NSCs. We also show that BMP4 may promote monkey NSC quiescence. Our study therefore provides implications for NSC-based cell therapy of brain injury in the future.