Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGF<i>β</i> Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Acid

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Transplantation sites</td><td class="align_center">ES R1 + RA5</td><td class="align_center">ES R1 + RA10</td><td class="align_center">EC F9 + RA5</td><td class="align_center">EC F9 + RA10</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">SC</td><td class="align_center">3/3 (100%), 6 wk</td><td class="align_center">4/4 (100%), 6 wk</td><td class="align_center">3/3 (100%), 6 wk</td><td class="align_center">0/6 (0%), 30 wk</td></tr><tr><td class="align_left">IP</td><td class="align_center">3/3 (100%), 6 wk</td><td class="align_center">4/4 (100%), 6 wk</td><td class="align_center">3/3 (100%), 6 wk</td><td class="align_center">0/8 (0%), 30 wk</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>The percentage and number of animals are indicated in which tumors were found in the transplantation sites during autopsy. SC: subcutaneous transplantation; IP: intraperitoneal transplantation (the cells grown on acetate cellulose membranes).<br/></td></tr></table>

Tumor development after transplantations of RA-stimulated ES R1 and EC F9 into immunodeficient nude mice.

Stem Cells International

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Table 1

Table 1: Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGF<i>β</i> Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Acid 

Table 1 | Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGFβ Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Acid 