Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells

<div>Kindlin-2 boosts iPSC-MSCs adhesion to slides coated with VCAM-1 + SDF1<i>α</i>. The iPSC-MSCs transfected with Kindlin-2 Flag and shRNA adhered to the flow chamber slide coated with VCAM-1/SDF-1<i>α</i> under shear stress. Kindlin-2 Flag transfected iPSC-MSCs had significantly higher attachment to the slides cocoated with VCAM-1 + SDF-1<i>α</i> under shear flow velocities of 0, 2, and 5 dynes/cm<sup>2</sup> with 10x magnification compared to control Flag. 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Stem Cells International

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Figure 5

Figure 5: Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells 