Induced Pluripotent Stem Cells Reduce Progression of Experimental Chronic Kidney Disease but Develop Wilms’ Tumors

<div>Characterization of induced pluripotent stem cells (iPSs). (a) Morphology of the iPS cell colonies. (b) Immunofluorescent staining of rat-induced pluripotent stem cells for the expression of the pluripotency markers OCT-4 (upper panels, scale bar 400 <i>μ</i>m) and SOX-17 (lower panels, scale bar 1000 <i>μ</i>m) and overlay with the control staining of the nucleus with DAPI (Sigma). (c) RT-PCR analysis of gene expression in undifferentiated riPS cells.</div>

Stem Cells International

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Figure 1: Induced Pluripotent Stem Cells Reduce Progression of Experimental Chronic Kidney Disease but Develop Wilms’ Tumors 