Induced Pluripotent Stem Cells Reduce Progression of Experimental Chronic Kidney Disease but Develop Wilms’ Tumors

Table 1

Renal function parameter measurements at the end of the study (day 60).

Parameters	Groups
	Sham	CKD	BMSC	iPS
SCr (mg/dL)	0.6 ± 0.1^a	1.2 ± 0.2	0.81 ± 0.13	0.94 ± 0.37
PT24h (mg/24 h)	1 ± 0.2^b,c,d	76.6 ± 41.5^f	57.12 ± 22^h	12.2 ± 42.6
CCr (mL/min)	0.75 ± 0.1^e	0.31 ± 0.04	0.66 ± 0.2^i	0.60 ± 0.2^j
RCCr (mL/min/d)	0.0001 ± 0.006	0.012 ± 0.002^g	0.007 ± 0.004	0.009 ± 0.006
Mean arterial pressure (mmHg)	127 ± 1	192 ± 35.7	178 ± 54.5	176 ± 59
Body weight change (g)	11 ± 48	−17.6 ± 22.2	5.8 ± 30.6	−12 ± 32

Results are mean ± SD. SCr = serum creatinine; RCCr = rate of decline of CCr; PT24h = 24-hour proteinuria; CCr = creatinine clearance; CKD = chronic kidney disease; BMSC = mesenchymal stem cell; iPS = induced pluripotent stem cells. ^a versus CKD; ^b versus CKD; ^c versus BMSC; ^d versus iPS; ^e versus CKD; ^f versus iPS; ^g versus BMSC; ^h versus iPS; ⁱ versus CKD; ^j versus CKD.