|
| Study | Animal model | Type of MSCs | Route of administration | Results |
|
| Arikura et al. (2004) [16] | Rats | BM-MSCs | Portal vein | (a) BM-MSCs from normal rats were infused via the PV into the livers of congenic Nagase’s analbuminemic rats immediately after 70% PH
(b) BM-MSCs transplantation in albumin-deficient rats resulted in albumin production 4 wks after transplantation |
|
| Seki et al. (2012) [17] | Rats | ADSCs | (a) Penile vein
(b) Femoral vein | (a) In I/R model higher LG rate was found than in shame/control groups
(b) Stasis of ADSCs in the periportal areas after injection of ADSCs but more in the central portion of the liver
(c) ADSCs’ transplantation promotes LG after PH, particularly in cases with repeated I/R |
|
| Sun et al. (2013) [18] | Rats | ADSCs | Tail vein | (a) The effects of serum from rats subjected to 70% PH on the differentiation ability of rat ADSCs in vitro were investigated, 24 h after PH
(b) The potential role of ADSCs in vivo following PH injury was also explored
(c) ADSCs were treated with serum from rats, differentiated into hepatocyte-like cells, expressed α-FP, secreted alb, synthesized urea, acquired cytochrome P450 activity, and upregulated the expression of IL-6 and HGF transiently in vitro, although the hepatic differentiation efficiency was extremely low
(d) Using ADSCs, liver injury was ameliorated and LG was promoted
(e) ADSCs, in vivo, after 24 h of 70% PH do not increase IL-6 and HGF expression |
|
| Saito et al. (2013) [19] | Mice | ADSCs | NR | (a) ADSCs have beneficial protective effects on liver injury and LG, after 70% PH and I/R
(b) VEGF and HGF secreted by ADSCs protect hepatocytes
(c) Suppression of VEGF by bevacizumab administration did not affect the protective effects of ADSCs
(d) ADSCs secrete HGF, VEGF, and FGF which restore liver function and promote LG |
|
| Li et al. (2013) [20] | Rats | BM-MSCs | (a) Portal vein
(b) Tail vein | (a) Rats received BM-MSCs through portal vein or tail vein, after a 70% PH
(b) Injected BM-MSCs can migrate to the damaged liver and differentiate into hepatocytes to promote LG after PH |
|
| Koellensperger et al. (2013) [21] | Rats | ADSCs | Hepatic parenchyma | (a) Rats received ADSCs with injection directly to the hepatic parenchyma, after 2/3 PH, chemically induced liver injury by retrosine and allyl alcohol
(b) Postoperatively, increased levels of albumin were retrieved
(c) MSCs were identified up to 12 weeks after transplantation |
|
| Tautenhahn et al. (2016) [14] | Rats | ADSCs | Splenic application | (a) Rats received ADSCs by splenic application following 90% PH
(b) Transplanted ADSCs were predifferentiated into hepatocytic cells
(c) ADSCs supported survival after PH
(d) ADSCs decreased liver-related blood parameters indicative for the improvement of liver function
(e) ADSCs decreased the apoptotic rate and increased the proliferation rate
(f) The experimental time period of 48 hours was too short to allow for integration of MSCs into the host liver
(g) MSCs ameliorated hepatic dysfunction and improved LG after extended resection by paracrine mechanisms
(h) They may represent a new therapeutic option to treat posthepatectomy acute liver failure |
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