Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Table 2

Specific data of included studies on MSCs transplantation in acute and chronic liver failure, liver fibrosis and liver cirrhosis models, type of MSCs, route of transplantation, and obtained results (chronological order of publication). In this table, results from minor endpoints of this study are presented.

Study	Animal model	Type of MSCs	Route of administration	Results
Abdel Aziz et al. (2007) [22]	Rats	BM-MSCs	Tail vein	(a) Isolated CD29+ MSCs from the BM of males and injected them into the tail vein in a female rat fibrosis model.; (b) The MSCs could differentiate into hepatocyte-like cells and reduce fibrosis by decreasing precipitation of collagen.
Okura et al. (2010) [23]	NOD-SCID mice	ADSCs; (To note that in this study, the authors used ADSCs of human origin)	NR	(a) A new method for generation of functional hepatocyte-like cell clusters is described, using floating culture. Induced functional hepatocyte-like cell clusters functioned effectively both in vitro & in vivo.; (b) The generated hepatocyte-like cell clusters were transplanted into NOD-SCID mouse with chronic liver injury, resulting in a significant improvement of serum alb & total brb levels.; (c) ADSCs limit severity of chronic hepatic failure and increase survival.
Harn et al. (2012) [24]	Rats	ADSCs	Direct liver injection	(a) The transplanted ADSCs differentiated into albumin  &  α-FP secreting liver-like cells, 1 week after transplantation.; (b) Liver function recovered significantly, as determined by biochemical analyses that analyzed total brb, PT & albumin levels; (c) ADSCs limit severity of chronic hepatic failure & increase survival.
Wang et al. (2012) [25]	Rats	ADSCs	(a) Portal vein; or; (b) Tail vein	(a) In a model of CCl4-induced liver fibrosis, authors administered ADSCs.; (b) Findings: increased portal vein perfusion and microcirculation improvement.; (c) Result: decreased fibrosis.
Seki et al. (2013) [26]	Mice	ADSCs	Directly to hepatic parenchyma	(a) Model of cirrhosis due to nonalcoholic steatohepatitis.; (b) ADSCs transplantation provoked downregulation of inflammatory cells.; (c) ADSCs favored liver regeneration by upregulation of regenerative genes.
Saidi et al. (2015) [27]	Mice	ADSCs; (to note that, in this study, the authors used ADSCs of human origin)	NR	(a) Model of CCl4-induced acute liver failure.; (b) Mice were treated with human ADSCs prior CCl4 induced acute liver failure.; (c) The results prove that ADSCs attenuated liver injury and improved survival.

NOD-SCID mouse: nonobese diabetic severe combined immunodeficiency mouse.