IGF1 and NRG1 Enhance Proliferation, Metabolic Maturity, and the Force-Frequency Response in hESC-Derived Engineered Cardiac Tissues

Table 2

Contraction and relaxation kinetics of engineered tissues.

Group	Stretch (n)	vup (mN/mm^2/s)	R50 (ms)	R90 (ms)
Control	30% (13)	9.41 ± 2.14	167 ± 13	326 ± 24
Control	10% (12)	2.89 ± 0.93	113 ± 13	232 ± 15
IGF1	30% (9)	5.01 ± 1.14	144 ± 10	277 ± 24
NRG1	30% (11)	2.38 ± 0.26	120 ± 9	243 ± 25
IGF1 + NRG1	30% (13)	2.19 ± 0.45	139 ± 9	278 ± 28

Peak upstroke velocity (v_up) and time to 50% and 90% relaxation (R₅₀ and R₉₀) of peak active stress, σ_a,max, was measured at the indicated stretch. Sample size is displayed in parentheses. and versus control.