Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells

Figure 1

Role of RGD peptide in cell adhesion during culture of BM-MSCs. (a) Experimental design for plain and modified RGD-alginate hydrogel. Photographs of human BM-MSCs adhered on the surface of (b) unmodified alginate hydrogel disc and (c) RGD-modified alginate hydrogel disc 1 day after cell plating. The profiles of BMP-2 release from RGD-modified alginate hydrogel disc with various thicknesses (0.5, 1.0, and 2.0 mm) (d) for 24 hours and (e) 10 days. The amount of BMP-2 released from various hydrogel discs was determined by ELISA. The values represent the mean ± standard deviation ().

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