Delayed Endothelial Progenitor Cell Therapy Promotes Bone Defect Repair in a Clinically Relevant Rat Model

Figure 2

Treatment of bone defects with EPCs improves radiographic healing. (a) Radiographic scores of rat femoral defects at 10 weeks. The difference between EPC treatment and control was statistically significant when treatment was applied acutely but not when treatment was performed in a delayed fashion. No difference was observed between delayed EPC and acute EPC groups. (b) Representative radiographs of defects in each group. Complete radiographic union was observed in all animals receiving EPCs, whereas control groups generally demonstrated incomplete union or nonunion. denotes significant difference between groups ().

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