Angiogenic Capacity of Dental Pulp Stem Cell Regulated by SDF-1α-CXCR4 Axis

Figure 4

The involvement of SDF-1α and CXCR4 axis in in vivo angiogenesis by DPSCs and HUVECs. The expression of angiogenic factors and receptors was verified by qPCR. (a) The expression of SDF-1α, PDGFRβ, and VEGF was higher in DPSCs than that in HUVECs. On the contrary, the expression of CXCR4, PDGF-BB, VEGFR1, and VEGFR2 was higher in HUVECs than that in DPSCs. . (b) To confirm the functional involvement of SDF-1α and CXCR4 axis in in vivo angiogenesis, AMD3100, an antagonist of CXCR4, was mixed with Matrigel plug. At 7 days postinjection, there were no microvessel-like structures in the AMD3100-treated group as compared to control group.

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