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Stem Cells International
Volume 2017, Article ID 8085462, 10 pages
https://doi.org/10.1155/2017/8085462
Research Article

Angiogenic Capacity of Dental Pulp Stem Cell Regulated by SDF-1α-CXCR4 Axis

1Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea
2Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Republic of Korea
3Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea
4Laboratory of Molecular Genetics, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea
5Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul 06351, Republic of Korea
6Department of Anatomy & Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea
7Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea

Correspondence should be addressed to Kyunghoon Lee; ude.ukks@hkeel and Sun-Ho Lee; moc.liamg@27attobos

Received 16 December 2016; Revised 26 February 2017; Accepted 1 March 2017; Published 15 May 2017

Academic Editor: Dominique Bonnet

Copyright © 2017 Hyun Nam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Gronthos, M. Mankani, J. Brahim, P. G. Robey, and S. Shi, “Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 25, pp. 13625–13630, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Iwasaki, M. Komaki, N. Yokoyama et al., “Periodontal ligament stem cells possess the characteristics of pericytes,” Journal of Periodontology, vol. 84, no. 10, pp. 1425–1433, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Janebodin, Y. Zeng, W. Buranaphatthana, N. Ieronimakis, and M. Reyes, “VEGFR2-dependent angiogenic capacity of pericyte-like dental pulp stem cells,” Journal of Dental Research, vol. 92, no. 6, pp. 524–531, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. J. H. Kim, G. H. Kim, J. W. Kim et al., “In vivo angiogenic capacity of stem cells from human exfoliated deciduous teeth with human umbilical vein endothelial cells,” Molecules and Cells, vol. 39, no. 11, pp. 790–796, 2016. View at Publisher · View at Google Scholar
  5. M. Crisan, S. Yap, L. Casteilla et al., “A perivascular origin for mesenchymal stem cells in multiple human organs,” Cell Stem Cell, vol. 3, no. 3, pp. 301–313, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Corselli, C. W. Chen, M. Crisan, L. Lazzari, and B. Peault, “Perivascular ancestors of adult multipotent stem cells,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 6, pp. 1104–1109, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J. M. Isner and T. Asahara, “Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization,” The Journal of Clinical Investigation, vol. 103, no. 9, pp. 1231–1236, 1999. View at Publisher · View at Google Scholar
  8. J. M. Isner, A. Pieczek, R. Schainfeld et al., “Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb,” Lancet, vol. 348, no. 9024, pp. 370–374, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. R. K. Jain, P. Au, J. Tam, D. G. Duda, and D. Fukumura, “Engineering vascularized tissue,” Nature Biotechnology, vol. 23, no. 7, pp. 821–823, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. J. M. Melero-Martin, Z. A. Khan, A. Picard, X. Wu, S. Paruchuri, and J. Bischoff, “In vivo vasculogenic potential of human blood-derived endothelial progenitor cells,” Blood, vol. 109, no. 11, pp. 4761–4768, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Au, L. M. Daheron, D. G. Duda et al., “Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels,” Blood, vol. 111, no. 3, pp. 1302–1305, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Aiuti, I. J. Webb, C. Bleul, T. Springer, and J. C. Gutierrez-Ramos, “The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood,” The Journal of Experimental Medicine, vol. 185, no. 1, pp. 111–120, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Mohle, F. Bautz, S. Rafii, M. A. Moore, W. Brugger, and L. Kanz, “The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1,” Blood, vol. 91, no. 12, pp. 4523–4530, 1998. View at Google Scholar
  14. T. Nagasawa, S. Hirota, K. Tachibana et al., “Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1,” Nature, vol. 382, no. 6592, pp. 635–638, 1996. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. R. Zou, A. H. Kottmann, M. Kuroda, I. Taniuchi, and D. R. Littman, “Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development,” Nature, vol. 393, no. 6685, pp. 595–599, 1998. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Peled, I. Petit, O. Kollet et al., “Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4,” Science, vol. 283, no. 5403, pp. 845–848, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Kucia, R. Reca, K. Miekus et al., “Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis,” Stem Cells, vol. 23, no. 7, pp. 879–894, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Imitola, K. Raddassi, K. I. Park et al., “Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 52, pp. 18117–18122, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Jiang, Y. Q. Zhu, R. Du et al., “The expression and role of stromal cell-derived factor-1alpha-CXCR4 axis in human dental pulp,” Journal of Endodontia, vol. 34, no. 8, pp. 939–944, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. Q. M. Gong, J. J. Quan, H. W. Jiang, and J. Q. Ling, “Regulation of the stromal cell-derived factor-1alpha-CXCR4 axis in human dental pulp cells,” Journal of Endodontia, vol. 36, no. 9, pp. 1499–1503, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Jiang, W. W. Peng, L. F. Li, Y. Yang, and Y. Q. Zhu, “Proliferation and multilineage potential of CXCR4-positive human dental pulp cells in vitro,” Journal of Endodontia, vol. 38, no. 5, pp. 642–647, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Bronckaers, P. Hilkens, Y. Fanton et al., “Angiogenic properties of human dental pulp stem cells,” PLoS One, vol. 8, no. 8, article e71104, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Hilkens, Y. Fanton, W. Martens et al., “Pro-angiogenic impact of dental stem cells in vitro and in vivo,” Stem Cell Research, vol. 12, no. 3, pp. 778–790, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Nakashima, K. Iohara, and M. Sugiyama, “Human dental pulp stem cells with highly angiogenic and neurogenic potential for possible use in pulp regeneration,” Cytokine & Growth Factor Reviews, vol. 20, no. 5-6, pp. 435–440, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. K. E. Lee, S. K. Lee, S. E. Jung, Z. Lee, and J. W. Kim, “Functional splicing assay of DSPP mutations in hereditary dentin defects,” Oral Diseases, vol. 17, no. 7, pp. 690–695, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. J. M. Melero-Martin, M. E. De Obaldia, S. Y. Kang et al., “Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells,” Circulation Research, vol. 103, no. 2, pp. 194–202, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Shi and S. Gronthos, “Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp,” Journal of Bone and Mineral Research, vol. 18, no. 4, pp. 696–704, 2003. View at Publisher · View at Google Scholar
  28. A. Armulik, A. Abramsson, and C. Betsholtz, “Endothelial/pericyte interactions,” Circulation Research, vol. 97, no. 6, pp. 512–523, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. K. Gaengel, G. Genove, A. Armulik, and C. Betsholtz, “Endothelial-mural cell signaling in vascular development and angiogenesis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 29, no. 5, pp. 630–638, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. J. D. Keene, “RNA regulons: coordination of post-transcriptional events,” Nature Reviews. Genetics, vol. 8, no. 7, pp. 533–543, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. P. R. Baraniak and T. C. McDevitt, “Stem cell paracrine actions and tissue regeneration,” Regenerative Medicine, vol. 5, no. 1, pp. 121–143, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. X. Liang, Y. Ding, Y. Zhang, H. F. Tse, and Q. Lian, “Paracrine mechanisms of mesenchymal stem cell-based therapy: current status and perspectives,” Cell Transplantation, vol. 23, no. 9, pp. 1045–1059, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Bronckaers, P. Hilkens, W. Martens et al., “Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis,” Pharmacology & Therapeutics, vol. 143, no. 2, pp. 181–196, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. C. Marchionni, L. Bonsi, F. Alviano et al., “Angiogenic potential of human dental pulp stromal (stem) cells,” International Journal of Immunopathology and Pharmacology, vol. 22, no. 3, pp. 699–706, 2009. View at Publisher · View at Google Scholar
  35. S. B. Goncalves, Z. Dong, C. M. Bramante, G. R. Holland, A. J. Smith, and J. E. Nor, “Tooth slice-based models for the study of human dental pulp angiogenesis,” Journal of Endodontia, vol. 33, no. 7, pp. 811–814, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. I. Petit, D. Jin, and S. Rafii, “The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis,” Trends in Immunology, vol. 28, no. 7, pp. 299–307, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. B. A. Teicher and S. P. Fricker, “CXCL12 (SDF-1)/CXCR4 pathway in cancer,” Clinical Cancer Research, vol. 16, no. 11, pp. 2927–2931, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. K. Wang, X. Zhao, C. Kuang et al., “Overexpression of SDF-1alpha enhanced migration and engraftment of cardiac stem cells and reduced infarcted size via CXCR4/PI3K pathway,” PLoS One, vol. 7, no. 9, article e43922, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Jaerve, J. Schira, and H. W. Muller, “Concise review: the potential of stromal cell-derived factor 1 and its receptors to promote stem cell functions in spinal cord repair,” Stem Cells Translational Medicine, vol. 1, no. 10, pp. 732–739, 2012. View at Publisher · View at Google Scholar · View at Scopus
  40. H. W. Jiang, J. Q. Ling, and Q. M. Gong, “The expression of stromal cell-derived factor 1 (SDF-1) in inflamed human dental pulp,” Journal of Endodontia, vol. 34, no. 11, pp. 1351–1354, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. L. Pierdomenico, L. Bonsi, M. Calvitti et al., “Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp,” Transplantation, vol. 80, no. 6, pp. 836–842, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. Y. Cao, M. Song, E. Kim et al., “Pulp-dentin regeneration: current state and future prospects,” Journal of Dental Research, vol. 94, no. 11, pp. 1544–1551, 2015. View at Publisher · View at Google Scholar · View at Scopus