Table of Contents Author Guidelines Submit a Manuscript
Stem Cells International
Volume 2017, Article ID 8715798, 12 pages
https://doi.org/10.1155/2017/8715798
Research Article

Neural Differentiation Is Inhibited through HIF1α/β-Catenin Signaling in Embryoid Bodies

1Department of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech Republic
2Institute of Biophysics, Academy of Sciences of the Czech Republic, 61265 Brno, Czech Republic
3International Clinical Research Center, St. Anne’s University Hospital, 65691 Brno, Czech Republic

Correspondence should be addressed to Josef Večeřa; zc.inum.ics@arecev

Received 12 June 2017; Accepted 2 October 2017; Published 20 December 2017

Academic Editor: Boon C. Heng

Copyright © 2017 Josef Večeřa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Okazaki and E. Maltepe, “Oxygen, epigenetics and stem cell fate,” Regenerative Medicine, vol. 1, pp. 71–83, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Quinn and G. M. Harlow, “The effect of oxygen on the development of preimplantation mouse embryos in vitro,” Journal of Experimental Zoology, vol. 206, pp. 73–80, 1978. View at Publisher · View at Google Scholar · View at Scopus
  3. J. E. Pabon Jr., W. E. Findley, and W. E. Gibbons, “The toxic effect of short exposures to the atmospheric oxygen concentration on early mouse embryonic development,” Fertility and Sterility, vol. 51, pp. 896–900, 1989. View at Publisher · View at Google Scholar
  4. Q.-L. Ying, J. Wray, J. Nichols et al., “The ground state of embryonic stem cell self-renewal,” Nature, vol. 453, pp. 519–523, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. D. L. Ramírez-Bergeron, A. Runge, K. D. C. Dahl, H. J. Fehling, G. Keller, and M. C. Simon, “Hypoxia affects mesoderm and enhances hemangioblast specification during early development,” Development, vol. 131, pp. 4623–4634, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. S.-W. Lee, H.-K. Jeong, J.-Y. Lee et al., “Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF,” EMBO Molecular Medicine, vol. 4, pp. 924–938, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Yamaguchi, “Heads or tails: Wnts and anterior–posterior patterning,” Current Biology, vol. 11, pp. 713–724, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Aubert, H. Dunstan, I. Chambers, and A. Smith, “Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation,” Nature Biotechnology, vol. 20, pp. 1240–1245, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. A. T. Naito, I. Shiojima, H. Akazawa et al., “Developmental stage-specific biphasic roles of Wnt/β-catenin signaling in cardiomyogenesis and hematopoiesis,” PNAS, vol. 103, pp. 19812–19817, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. D. ten Berge, W. Koole, C. Fuerer, M. Fish, E. Eroglu, and R. Nusse, “Wnt signaling mediates self-organization and axis formation in embryoid bodies,” Cell Stem Cell, vol. 3, pp. 508–518, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. A. J. Majmundar, W. J. Wong, and M. C. Simon, “Hypoxia-inducible factors and the response to hypoxic stress,” Molecular Cell, vol. 40, pp. 294–309, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. R. P. Singh, K. Franke, and B. Wielockx, “Hypoxia-mediated regulation of stem cell fate,” High Altitude Medicine & Biology, vol. 13, pp. 162–168, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Kudová, J. Procházková, O. Vašiček et al., “HIF-1alpha deficiency attenuates the cardiomyogenesis of mouse embryonic stem cells,” PLoS One, vol. 11, pp. 1–17, 2016. View at Publisher · View at Google Scholar · View at Scopus
  14. M. V. Gustafsson, X. Zheng, T. Pereira et al., “Hypoxia requires notch signaling to maintain the undifferentiated cell state,” Developmental Cell, vol. 9, pp. 617–628, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Mazumdar, W. T. O’Brien, R. S. Johnson et al., “O2 regulates stem cells through Wnt/β-catenin signalling,” Nature Cell Biology, vol. 12, pp. 1007–1013, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. C. E. Murry and G. Keller, “Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development,” Cell, vol. 132, pp. 661–680, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Kotasová, J. Procházková, and J. Pacherník, “Interaction of Notch and gp130 signaling in the maintenance of neural stem and progenitor cells,” Cellular and Molecular Neurobiology, vol. 34, pp. 1–15, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Roitbak, L. Li, and L. A. Cunningham, “Neural stem/progenitor cells promote endothelial cell morphogenesis and protect endothelial cells against ischemia via HIF-1α-regulated VEGF signaling,” Journal of Cerebral Blood Flow and Metabolism, vol. 28, pp. 1530–1542, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Tomita, M. Ueno, M. Sakamoto et al., “Defective brain development in mice lacking the Hif-1α gene in neural,” Cell, vol. 23, pp. 6739–6749, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. M. T. Veeman, D. C. Slusarski, A. Kaykas, S. H. Louie, and R. T. Moon, “Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements,” Current Biology, vol. 13, pp. 680–685, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Salic, E. Lee, L. Mayer, and M. W. Kirschner, “Control of β-catenin stability: reconstitution of the cytoplasmic steps of the Wnt pathway in Xenopus egg extracts,” Molecular Cell, vol. 5, pp. 523–532, 2000. View at Publisher · View at Google Scholar
  22. A. Kaidi, A. C. Williams, and C. Paraskeva, “Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia,” Nature Cell Biology, vol. 9, pp. 210–217, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. Q. Zhang, X. Bai, W. Chen et al., “Wnt/β-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling,” Carcinogenesis, vol. 34, pp. 962–973, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. A. J. Majmundar, D. S. M. Lee, N. Skuli et al., “HIF modulation of Wnt signaling regulates skeletal myogenesis in vivo,” Development, vol. 142, pp. 2405–2412, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. T. L. Medley, M. Furtado, N. T. Lam et al., “Effect of oxygen on cardiac differentiation in mouse iPS cells: role of hypoxia inducible factor-1 and Wnt/beta-catenin signaling,” PLoS One, vol. 8, pp. 1–8, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Čajánek, D. Ribeiro, I. Liste, C. L. Parish, V. Bryja, and E. Arenas, “Wnt/β-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells,” Stem Cells, vol. 27, pp. 2917–2927, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. G. J. Woodhead, C. A. Mutch, E. C. Olson, and A. Chenn, “Cell-autonomous β-catenin signaling regulates cortical precursor proliferation,” Journal of Neuroscience, vol. 26, pp. 12620–12630, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Rudloff and R. Kemler, “Differential requirements for β-catenin during mouse development,” Development, vol. 139, pp. 3711–3721, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Sato, M. Inoue, T. Yoshizawa, and K. Yamagata, “Moderate hypoxia induces β-cell dysfunction with HIF-1-independent gene expression changes,” PLoS One, vol. 9, pp. 1–20, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. S. N. Sansom, D. S. Griffiths, A. Faedo et al., “The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis,” PLoS Genetics, vol. 5, article e1000511, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. O. Machon, M. Backman, O. Machonova et al., “A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus,” Developmental Biology, vol. 311, pp. 223–237, 2007. View at Publisher · View at Google Scholar · View at Scopus