Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

<div>Localization and functions of VitC-dependent mono- and dioxygenase enzymes. ALK: RNA and DNA demethylase family; JMJ: jumonji histone demethylases; TET: ten-eleven translocation DNA demethylases; OGFO: 2-oxoglutarate- and Fe<sup>2+</sup>-dependent oxygenase; PLOD: procollagen-lysine_<i>α</i>-KG_5-dioxygenases; P3H: collagen prolyl 3-hydroxylase; P4H: collagen prolyl 4-hydroxylases; BBOX1: <i>γ</i>-butyrobetaine dioxygenases; DBH: dopamine beta-monooxygenase; PHD: HIF-prolyl hydroxylase; FIH: factor inhibiting HIF.</div>

Stem Cells International

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Figure 2: Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics 