Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a
MM exosomes increased miR-21 and miR-146a levels in MSCs. (a) A representative picture of exosomes purified from OPM2 cells, examined by NTS300. (b) The expressions of miRs (miR-21, miR-146a) in parent MM cells (OPM2, RPMI-8226, and U266) and exosomes were measured by qPCR. (c) Fluorescence images of MSCs following the uptaking of OPM2-exo labeled with PKH26 (red) for 24 hours. (d) MSCs were cultured with OPM2-exo and the normalized expressions of miRs (miR-21, miR-146a) in MSCs were detected by qPCR. Results were shown as mean ± S.E.M. (, compared to untreated MSCs, /group).
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