Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a
The effect of OPM2-exo on the proliferation of MSCs. (a) MSCs were treated with different concentrations of OPM2-exo for 4 days and proliferation was evaluated by using MTT assay. (b) MSCs were treated with different concentrations of OPM2-exo for 4 days and proliferation was evaluated by using CCK-8 assay. (c) Representative microscopy images of MSCs treated for 10 days with OPM2-exo (80 μg/ml). 10x magnification in microscopy. Representative images of three independent experiments were reported at day 1, day 4, and day 10. (d) MSCs were treated with OPM2-exo (80 μg/ml) and the cell number was counted by automated counter after day 1, day 4, and day 10, respectively. Results were shown as mean ± S.E.M. (, compared to untreated MSCs; #, compared to day 1; /group).
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