Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a
The effects of OPM2-exo on the CAF transformation and IL-6 secretion of MSCs. (a) Effect of OPM2-exo (80 μg/ml) on the expressions of CAF transformation markers (FAP, α-SMA, and SDF-1) in MSCs at day 10. Data were expressed as normalized to GAPDH. Statistical analysis was performed by t-test. (b) Effect of OPM2-exo (80 μg/ml) on IL-6 mRNA expression and IL-6 secretion of MSCs at day 10. Results were shown as mean ± S.E.M. (, compared to untreated MSCs; #, compared to day 1; /group).
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