Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a
Inhibition of miR-21 decreased the proliferation and CAF transformation of MSCs. (a) MSCs were subjected to vehicle (veh) treatment and transfected with miRCtrl or miR-21 as indicated, and 10 days later, the miR-21 level was measured by qRT-PCR. (b) Effect of downregulating miR-21 on the proliferation of MSCs at day 4. (c) Effect of downregulating miR-21 on the expressions of CAF transformation markers in MSCs at day 10. Results were shown as mean ± S.E.M. ( versus veh; # versus miRCtrl, /group).
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