Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a
Inhibition of miR-146a decreased IL-6 secretion of MSCs. (a) MSCs were subjected to veh treatment and transfected with miRCtrl or miR-146a as indicated and 10 days later the miR-146a level was measured by qRT-PCR. (b) Effect of downregulating miR-146a on the IL-6 mRNA expression of MSCs at day 10. (c) Effect of downregulating miR-146a on the IL-6 secretion of MSCs at day 10. Results were shown as mean ± S.E.M. ( versus veh; # versus miRCtrl, /group).
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