Bone Regeneration Induced by Bone Porcine Block with Bone Marrow Stromal Stem Cells in a Minipig Model of Mandibular “Critical Size” Defect

Figure 6

(a) BPB group. Bone tissue was deposited in the block material (BPB). No fibrous tissue was observed in the defect area. Vessels (V) were present in the central part of the bone defects. New bone (NB) and osteoblasts in close contact with the block material acid fuchsin and toluidine blue. Bar = 100 μ. (b) BPB/BMSSCs group. Mature bone (MB) in the bone defect. Bone morphology was more mature and well organized, presenting a primary osteon. A basic multicellular unit of osteoclasts cells (yellow arrows) that dissolves an area of the bone surface and then fills it with new bone by osteoblasts (white arrows) to form haversian systems or osteons. A vessels (V) were present in the central part of the bone defects. Acid fuchsin and toluidine blue. Bar = 100 μ.

(a)

(b)