The Effects of Different Factors on the Behavior of Neural Stem Cells

Figure 1

Effects of different proteins on the Wnt signaling pathway. (a) The increase in the expression of Wnt7a activated the Wnt7a/β-catenin-cyclinD1 pathway, which stimulated the proliferation of NSCs, and induced the Wnt7a/β-catenin-Ngn2 pathway, which promoted the neuronal differentiation (the red arrows). In the cerebral cortex of mice, the overexpression of Wnt7a could increase the level of Ngn-1 mRNA and then induce the differentiation of NSCs into neurons (the green arrows). (b) The overexpression of Wnt3a activated the Wnt signaling pathway and promoted the proliferation and neuronal differentiation of NSCs. (c) The loss of FMRP resulted in a decrease in the level of β-catenin, then downregulated the expression of Ngn-1 and reduced neuronal differentiation.

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