|
| Drugs or active ingredients | Cells | The role of proliferation | The role of differentiation | Mechanism |
|
| Salvianolic acid B [21] | NSCs from cortex of E13.5 mice | Nestin-positive cells ↑ | The expression of tau ↑; the expression of GFAP ↓ | Cells in G2/S phase |
| Tetramethylpyrazine [23] | NSCs from cortex of E15 SD fetal rats | BrdU-positive cells ↑ | β-Tubulin III-positive cells ↑; β-tubulin III/nestin-positive cells ↑; GFAP-positive cells ↓; GFAP/nestin-positive cells ↓ | The expression of cyclin D1 ↑; the expression of P-ERK ↑; the expression of P-JNK with little change; the phosphorylation of P38 ↓ |
| Epimedium flavonoids [24] | NSCs from hippocampus of 1d neonatal rats | BrdU-positive cells ↑ | Tuj1-positive cells ↑; NF-200-positive cells ↑; GFAP-positive cells ↑ | |
| Panax notoginseng saponins [25] | NSCs from hippocampus of 1d neonatal rats | Nestin-positive cells ↑; BrdU-positive cells ↑ | Nestin/BrdU-positive cells ↑;
nestin/vimentin-positive cells ↑;
nestin/Tuj1-positive cells ↑ | |
| Tenuigenin [26] | NSCs from hippocampus of E16 rats | BrdU-positive cells ↑ | β-Tubulin III-positive cells ↑;
GFAP-positive cells ↑ | |
| Gastrodiae rhizome [27] | NSCs from human embryos | Viability ↑ | The expression of nestin ↓;
the expression of Tuj1 ↑;
the expression of MAP2 ↑;
dendrites ↑ | The expression of Sox2 ↓ |
| Astragaloside IV [28] | NSCs from hippocampus of adult SD rats | BrdU-positive cells ↑ | BrdU/MAP2-positive cells ↑;
BrdU/GFAP-positive cells ↑ | The expression of NGF ↑ |
| Angelica [29] | NSCs from embryonic rats | Nestin ↓ compared with the hypoxia group; nestin ↑ compared with the control group | | |
| Ketamine [31] | NSCs from the SVZ of 7d neonatal male SD rats | Nestin/BrdU-positive cells ↓ | The expression of β-tubulin III ↑;
the expression of GFAP ↓; the expression of nestin ↓ | |
| Fingolimod [34] | NSCs from E13.5 SD rats | CCK-8 ↑ | The expression of GFAP ↑ | |
| Simvastatin [36] | NSCs from embryonic rats | Nestin-positive cells ↑ | GFAP-positive cells ↑;
MAP2-positive cells ↑ | The expression of Notch1 ↑ |
|
