Paracrine Potential of the Human Adipose Tissue-Derived Stem Cells to Modulate Balance between Matrix Metalloproteinases and Their Inhibitors in the Osteoarthritic Cartilage In Vitro

<div>Scheme of coculture experiment of human osteoarthritic (OA) cartilage explants (CE) derived from cartilage remaining after joint replacement surgery, cultured alone or together with adipose tissue-derived stem cells (ASC) in monolayer. Experiments were performed in the following: (1) incomplete chondrocyte medium (IM), (2) IM supplemented with 2% human platelet growth factor-enriched plasma (PP), and (3) in IM + PP with interleukin- (IL-) 1<i>β</i>.</div>

Stem Cells International

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Figure 1

Figure 1: Paracrine Potential of the Human Adipose Tissue-Derived Stem Cells to Modulate Balance between Matrix Metalloproteinases and Their Inhibitors in the Osteoarthritic Cartilage In Vitro 

Figure 1 | Paracrine Potential of the Human Adipose Tissue-Derived Stem Cells to Modulate Balance between Matrix Metalloproteinases and Their Inhibitors in the Osteoarthritic Cartilage In Vitro 