Extracellular Vesicles from Adipose-Derived Mesenchymal Stem/Stromal Cells Accelerate Migration and Activate AKT Pathway in Human Keratinocytes and Fibroblasts Independently of miR-205 Activity

Figure 5

Gel enriched with extracellular vesicles derived from mesenchymal stem/stromal cells accelerated wound healing in rat excisional wound-splinting model. (a) Representative photographs of rat skin wounds that were either untreated (left column), exposed to hydroxyethyl cellulose gel (middle column), or exposed to hydroxyethyl cellulose gel enriched with extracellular vesicles (EVs) derived from mesenchymal stem/stromal cells at different time points of the experiment (7, 14, and 21 days after the wound was created). (b) Comparison of relative wound areas between negative control (gel) and test groups (gel + EVs). Data are presented as the mean ± standard deviation of three biological independent experiments. Statistical significance of differences is indicated as follows: .