Efficiency of Cell Therapy to GC-Induced ONFH: BMSCs with Dkk-1 Interference Is Not Superior to Unmodified BMSCs

Figure 5

Immunohistochemical analyses for expression of Dkk-1(a), GSK3β (b), β-catenin (c), Runx2 (d), or PPARγ (e) in femoral head specimens from 4 group rats. Dkk-1 positive percentage in the control group was stronger than the rest, while the positive rate in LDRM was significantly weaker than LEM or BMSC. GSK-3β positive. Similarly, GSK3β positive rate in the control group was significantly stronger than others (). Positive rate of β-catenin or Runx2 was significantly higher in LDRM, LEM, or BMSC (but within these three) than the control group (). PPARγ, with its strongest positive rate in the control group, was significantly higher than the LDRM, LEM, or BMSC ( within these three as well) (scale bar = 50 μm. NS, ; ).

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