Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Soluble factors</td><td class="align_center">Biological function</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">IDO</td><td class="align_center">Suppressing proliferation and effect of immune cells</td></tr><tr><td class="align_left">TSG6</td><td class="align_center">Anti-inflammatory effect</td></tr><tr><td class="align_left">NO</td><td class="align_center">Suppressing proliferation and modulation of T cell, promoting apoptosis of immune cells</td></tr><tr><td class="align_left">IL-10</td><td class="align_center">Suppressing apoptosis of immune cells</td></tr><tr><td class="align_left">CCL2</td><td class="align_center">Suppressing activation and migration of TH17 cells, promoting migration of monocyte</td></tr><tr><td class="align_left">PGE2</td><td class="align_center">Suppressing generation and migration of TNF, proliferation of T cell, and cytolytic activity of NK cell</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Biological function of soluble factor secreted by MSCs.</div>

Stem Cells International

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Table 2

Table 2: Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application 