Therapeutic Effects of VEGF Gene-Transfected BMSCs Transplantation on Thin Endometrium in the Rat Model

Figure 3

Protein expression of markers for endometrial cells and endometrial receptivity with Western blotting. (A, B, C, D) represent the control group, BMSC group, VEGF-BMSC group, and sham operation group 4 days after treatment, respectively. (A, B, C, D) mean these four groups 8 days after treatment. Vimentin, integrin α_νβ₃, and LIF protein expressions were gradually increased in the control, BMSC, VEGF-BMSC, and sham operation groups, respectively. VEGF-BMSC group showed a significantly higher expression of these four proteins compared with those of control group (). VEGF expression level was the highest in the VEGF-BMSC group, followed by BMSC group, sham operation group, and control group. The cytokeratin expression level in the VEGF-BMSC group was significantly higher compared with the control group. When compared day 4 with day 8 after stem cells transplantation, there was no significant difference in the expressions of those proteins.