Review Article

Applications of Mesenchymal Stem Cells in Sinus Lift Augmentation as a Dental Implant Technology

Table 1

The research works related to stem cell therapy in sinus lift augmentation.

Aim of the research workType of experimentMain finding(s)Reference

Using BM-MSCs for maxillary sinus floor elevation and bone formationIn vitroThe differentiation of BM-MSCs into osteoblasts was significantly increased, and also, formation of new bone was enhanced after implantation of BM-MSCs during maxillary sinus floor elevation.[15]
The usefulness of MSCs and the BMAC with BBM for sinus augmentationIn vivo (on 16 sheep)New bone formation due to BBM and MSC application[24]
Renewal of maxillary sinus deficiencies the using stem cellsOn 30 human participantsHigher density of the engineered bone in patients that received stem cells
Enriched CD90+ populations are harmless for maxillary sinus floor rebuilding, and they can also be used to accelerate and improve tissue-engineered bone quality.
[16]
Testing the potential of different stem cell sources about maxillary sinus augmentationIn vivo (6 beagles)The tissue-engineered bone complexes might be a worthy choice for augmentation of the maxillary sinus in edentulous patients because seeding of PDLSCs or BM-MSCs onto Bio-Oss can encourage bone formation and mineralization.[13]
Gabapentin-lactam (GBP-L) in enhancing new bone formationIn vivo (10 adult sheep)The osteogenic potency of the MSCs and new bone formation in tight contact with the original bone[25]
Sinus lifting using bovine bone mineral and autogenous bone marrow concentrate or autogenous boneIn 12 edentulous patientsNo implants failed on the control side during osseointegration.
No clinically related alterations concerning soft tissue parameters or peri-implant bone loss after one year
[17]
The bone formation capacity of ADSCs and BMSCsIn a canine sinus floor augmentation modelMore proliferative ability as well as larger osteogenic differentiation potential for BMSCs
Promoted fast and larger bone regeneration for BMSCs
[14]
The bone regenerative property of the amniotic epithelial cells (AECs) (an emerging source of progenitor cells) loaded on calcium phosphateIn vivo (in six adult sheep)Allotransplanted AECs influenced positively on scaffold integration and bone deposition
A decreased fibrotic reaction and a restricted inflammatory response as well as an improved angiogenesis
Direct participation in bone deposition related to oAEC entrapment within osteoid matrix
[11]